Investigating an effective method for the synthesis of thiazolidines using ureabenzoic acid

Abstract

Green chemistry, which is known as one of the most effective methods to prevent polution at the molecular level, is of great importance in industry and technology. Using suitable catalysts is one of the basic principles of green chemistry. In line with these goals, a quick, efficient, easy and environmentally Compatible synthesis of thiazolidine derivatives using nanocatalyst Fe₃O₄@SiO₂@(CH₂)₃-urea-benzoic acid has been reported. The described catalyst, with its unique structure, shows excellent catalytic activity in the synthesis of thiazolidine derivatives using the three-component interaction of 4-chlorobenzaldehyde, 2-aminobenzothiazole and 2-mercaptoacetic acid under solvent-free conditions with high efficiency. The mentioned catalyst is stable in interaction conditions and can be recycled at least 4 times without losing its catalytic activity. The compounds synthesized in this research are nitrogen-containing heterocycles containing four rings. These compounds have attracted a lot of attention due to their use in many biological and medicinal processes. Recent research shows that these compounds are used as anti-coagulant, anti-AIDS, anti-fungal and anti-bacterial drugs.of 4-chlorobenzaldehyde, 2-aminobenzothiazole and 2-mercaptoacetic acid under solvent-free conditions with high efficiency. The mentioned catalyst is stable in interaction conditions and can be recycled at least 4 times without losing its catalytic activity. The compounds synthesized in this research are nitrogen-containing heterocycles containing four rings. These compounds have attracted a lot of attention due to their use in many biological and medicinal processes. Recent research shows that these compounds are used as anti-coagulant, anti-AIDS, anti-fungal and anti-bacterial drugs.